Fig. 1.

The uterine transcriptome is dysregulated in mice that lack glands. RNA-sequencing was performed using uteri from gland-containing Ltf^iCre/+Foxa2^f/f glandless Pgr^Cre/+Foxa2^f/f, and control mice on GD 4. a Heatmap of the top 150 differentially expressed genes (log2 FPKM values) in FOXA2-deficient mice compared to controls. b Venn diagram comparing unique or common transcripts between the uterus of gland-containing Ltf^iCre/+Foxa2^f/f, glandless Pgr^Cre/+Foxa2^f/f, and control mice on GD 4. The LE vs GE represents genes that were enriched in the GE compared to the LE on GD 4. Superscripts denote genes combined for analysis. c Receptor and ligand interactions between genes uniquely differentially expressed in the uteri of glandless mice that are also enriched in GE on GD 4. Black boxes indicate genes uniquely differentially expressed in uteri of glandless Pgr^Cre/+Foxa2^f/f compared to control mice. Circles represent ligands, and half circles are receptors. All analysis was conducted using four biological replicates