Table 1.

Pharmacokinetic effects of drugs formulated with polysorbate 80

Drug	Effect of polysorbate 80
Preclinical studies
Doxorubicin [20]	Increased concentration in plasma
Methotrexate [21]	Increased uptake in brain Increased absorption Increased excretion into bile
Etoposide [22]	Increased AUC and decreased elimination
Clinical studies
Doxorubicin [23]	Increased volume of distribution up to 3-fold Decreased AUC up to 2-fold Increased clearance up to 2-fold
Paclitaxel [24]	Increased concentration in brain
Docetaxel [25]	Increased fraction unbound in plasma

AUC area under the plasma concentration-time curve