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三种IHC评分方法检测EGFR突变的相关数据比较

Comparison of three different criteria in detecting EGFR mutations by IHC

Criteria	Sensitivity	Specificity	PPV	NPV	Cohen’s Kappa 95%CI
PPV: positive predictive value; NPV: negative predictive value; EGFR: epidermal growth factor receptor; IHC: immunohistochemistry.
A	45.6%	88.5%	89.7%	42.6%	0.264 (0.134, 0.410)
B1	52.6%	80.8%	85.7%	43.8%	0.272 (0.116, 0.464)
B2	29.8%	92.3%	89.5%	37.5%	0.158 (0.025, 0.301)