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. 2015 May 20;18(5):315–320. [Article in Chinese] doi: 10.3779/j.issn.1009-3419.2015.05.10

2.

氟维司群联合EGFR-TKI治疗晚期NSCLC的Ⅱ期临床试验

Ongoing phase Ⅱ clinical trials of hormonal therapy in advanced NSCLC

ClinicalTrials.gov identifier Patient population Preselected biomarker Treatment
NSCLC: non-small cell lung cancer.
NCT01556191 Stage Ⅲ or Ⅳ NSCLC,
postmenopausal women
EGFR mutation Gefitinib + fulvestrant vs gefitinib
NCT01556191 Stage Ⅲ or Ⅳ NSCLC,
postmenopausal women
EGFR wildtype Erlotinib + fulvestrant vs erlotinib
NCT00592007 Stage Ⅲb or Ⅳ NSCLC, both gender ER and PR expression Erlotinib + fulvestrant
NCT00100854 Stage Ⅲb or Ⅳ NSCLC, both
gender
None Erlotinib + Fulvestrant
vs erlotinib
NCT00932152 Stage Ⅲb or Ⅳ, postmenopausal women None (1) Best supportive care
(2) Bevacizumab
(3) Fulvestrant + anastrozole
(4) Fulvestrant + anastrazole + bevacizumab