Fig. 5.

Potential role for Chm7 and Heh2 in surveillance of damaged NPCs. Mis-assembled NPCs are cleared in an ESCRT-III and proteasome dependent manner. In one model of misassembly, NPCs lacking Nup116 are encapsulated by new membrane to seal them off and prevent them participating in nucleocytoplasmic transport. The N-terminal domain of the INM LEM-domain protein Heh2 interacts with both Snf7 and the CHMP-like C-terminus of Chm7 and may play a role in this, from an ESCRT-III perspective, topologically satisfying closure. Hypothesis and figure suggested by Lusk and colleagues and drawn and adapted from [141], [170].