Table 3.
Bivariate Analyses Between Blood Lipids in Twin and SNP Models
| Pairs | rP (SE) | BM | Bivariate a2 (SE), % | Bivariate d2 (SE), %a | rA (SE) | rD (SE)a | rE (SE) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Twin | SNP | Twin | Twin | SNP | Twin | Twin | SNP | |||
| Triglycerides‐HDL | −0.46 (0.01)b | AE | 66 (3)b | 29 (6)b | ··· | −0.51 (0.02)b | −0.48 (0.13)b | ··· | −0.39 (0.02)b | −0.45 (0.11)b |
| Triglycerides–non‐HDL | 0.41 (0.01)b | ADE | 33 (14)b | 11 (6) | 23 (15) | 0.43 (0.15)b | 0.23 (0.20) | 0.49 (0.51) | 0.38 (0.03)b | 0.46 (0.05)b |
| HDL‐apoA1 | 0.84 (0.02)b | ACEc | 66 (2)b | 21 (6)b | ··· | 0.89 (0.01)b | 0.88 (0.06)b | ··· | 0.85 (0.01)b | 0.84 (0.05)b |
| TC‐LDL | 0.94 (0.02)b | ADE | 25 (8)b | 15 (6)b | 21 (9)b | 0.92 (0.04)b | 0.92 (0.04)b | 0.94 (0.06)b | 0.95 (0.00)b | 0.94 (0.04)b |
| TC‐apoB | 0.87 (0.02)b | AE | 46 (2)b | 14 (6)b | ··· | 0.83 (0.01)b | 0.82 (0.09)b | ··· | 0.91 (0.00)b | 0.87 (0.07)b |
| TC–non‐HDL | 0.93 (0.02)b | ADE | 25 (8)b | 13 (6)b | 22 (9)b | 0.88 (0.05)b | 0.89 (0.05)b | −0.96 (0.04)b | 0.96 (0.00)b | 0.94 (0.05)b |
| LDL‐apoB | 0.91 (0.02)b | ACEc | 47 (2)b | 14 (6)b | ··· | 0.91 (0.01)b | 0.89 (0.06)b | ··· | 0.92 (0.00)b | 0.91 (0.05)b |
| LDL–non‐HDL | 0.97 (0.02)b | ADE | 23 (8)b | 14 (6)b | 25 (9)b | 0.94 (0.03)b | 0.95 (0.03)b | 0.98 (0.02)b | 0.96 (0.00)b | 0.96 (0.03)b |
| ApoB–non‐HDL | 0.94 (0.02)b | ACEc | 47 (2)b | 14 (6)b | ··· | 0.95 (0.01)b | 0.96 (0.03)b | ··· | 0.95 (0.00)b | 0.93 (0.03)b |
a2 Indicates additive genetic variance; ACE, model including a2, common (c2), and nonshared environmental (e2) components; ADE, model including a2, d2, and e2; AE, model including a2 and e2; apoA1, apolipoprotein A1; apoB, apolipoprotein B; BM, best‐fitted model according to Akaike information criterion; d2, dominant genetic variance; HDL, high‐density lipoprotein; LDL, low‐density lipoprotein; rA, additive genetic correlation; rD, dominant genetic correlation; rE, nonshared environmental correlation; rP, phenotypic correlation; SNP, single‐nucleotide polymorphism–based genomic relatedness matrix restricted maximum likelihood model; TC, total cholesterol.
Bivariate d2 and rD are not significantly identified from SNP models for any pairs.
Statistically significant estimates (P<0.05).
ACE is the best‐fitted model, but bivariate c2=0% (SE=1%).