Table 5.
Sensitivity Analysis: Association Between Exposure (Any HPD or Preeclampsia Specifically) With Future AF (Per Woman), With and Without Adjusting for Hypertensiona and BMI >30b, After Exclusionsc (n=86 Cases and Controls)
| Factor | Model 1 Unadjusted | Model 2 Adjusted for Hypertension | Model 3 Adjusted for BMI | Model 4 Adjusted for Both | ||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P Valued | Adjusted OR (95% CI) | P Valued | Adjusted OR (95% CI) | P Valued | Adjusted OR (95% CI) | P Valued | |
| Any HPDe | 2.63 (1.12, 6.85) | 0.024 | 2.09 (0.85–5.62) | 0.11 | 2.32 (0.96–6.19) | 0.050 | 2.04 (0.82–5.54) | 0.10 |
| Hypertensiona | ··· | 1.95 (0.96–4.17) | 0.050 | ··· | 1.53 (0.71–3.39) | 0.28 | ||
| BMI >30b | ··· | ··· | 4.37 (1.21–23.84) | 0.013 | 3.47 (0.89–19.85) | 0.058 | ||
| Preeclampsiaf | 1.40 (0.38, 5.59) | 0.77 | 1.08 (0.28–4.53) | 1.00 | 1.13 (0.29–4.68) | 1.00 | 0.98 (0.25–4.13) | 1.00 |
| Hypertensiona | ··· | 2.27 (1.14–4.77) | 0.013 | ··· | 1.77 (0.84–3.86) | 0.12 | ||
| BMI >30b | ··· | ··· | 4.88 (1.38–26.39) | 0.007 | 3.54 (0.92–20.12) | 0.060 | ||
AF indicates atrial fibrillation; BMI, body mass index; CI, confidence interval; HPD, hypertensive pregnancy disorder; OR, odds ratio.
Hypertension at the time of index date.
BMI >30 at any first prenatal visit.
After excluding 19 women who had other structural heart disease or rheumatic or other valvular disease and their matched pairs.
Exact P value derived from score statistic from fitting a conditional logistic regression model.
The prevalence of HPD was 26.7% (23/86) and 11.6% (10/86) among AF cases and controls, respectively.
The prevalence of preeclampsia was 8.1% (7/86) and 5.8% (5/86) among AF cases and controls, respectively.