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. 2018 May 3;7(10):e007931. doi: 10.1161/JAHA.117.007931

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Cumulative incidence of coronary heart disease (CHD), heart failure (HF), and all‐cause mortality in FHS (Framingham Heart Study) by tertiles of plasma C24:0/C16:0 ceramide ratio. Cumulative incidence of CHD (A), HF (B), and all‐cause mortality (C) are reported for tertiles of C24:0/C16:0 ceramide ratio. Tertile 1 includes participants with ceramide levels at the 33rd percentile or lower (2.8–12.3 μg/mL); tertile 2 includes participants with ceramide levels between >33rd and <66th percentile (12.3–15.1 μg/mL); tertile 3 includes participants with ceramide levels ≥66th percentile (15.1–29.2 μg/mL).