Table 3.
Different Characteristics of Patients With and Those Without SCB‐Induced VTAs
| Pilsicainide‐Induced VTA+ (n=24) | Pilsicainide‐Induced VTA− (n=221) | P Valuea | |
|---|---|---|---|
| Clinical parameters | |||
| Male | 24 (100%) | 216 (98%) | 1.0000 |
| Age, y | 42.7±11.3 | 46.6±13.2 | 0.1478 |
| Symptomatic patients | 13 (54%) | 78 (35%) | 0.0782 |
| Syncope | 9 (38%) | 70 (32%) | 0.6464 |
| VT/VF | 4 (17%) | 8 (4%) | 0.0207 |
| Family history of SD | 10 (42%) | 62 (28%) | 0.1659 |
| SCN5A mutation | 4/20 (20%) | 12/119 (10%) | 0.2386 |
| VT/VF during follow‐up | 12 (50%) | 19 (9%) | <0.0001 |
| ECG parameters | |||
| Spontaneous type 1 ECG | 23 (96%) | 158 (71%) | 0.0068 |
| PQ interval in lead II (ms) | |||
| Pre SCB | 185±26 | 180±27 | 0.3227 |
| Post SCB | 242±43 | 227±36 | 0.0578 |
| QRS width (ms) | |||
| V1 | |||
| Pre SCB | 113±22 | 105±13 | 0.0969 |
| Post SCB | 145±36 | 131±21 | 0.0576 |
| V2 | |||
| Pre SCB | 114±21 | 106±13 | 0.0429 |
| Post SCB | 146±33 | 134±22 | 0.0748 |
| ST level (mV) | |||
| V1 | |||
| Pre SCB | 0.200±0.132 | 0.153±0.102 | 0.0307 |
| Post SCB | 0.385±0.219 | 0.257±0.162 | 0.0037 |
| V2 | |||
| Pre SCB | 0.307±0.194 | 0.293±0.157 | 0.9613 |
| Post SCB | 0.599±0.295 | 0.91±0.276 | 0.8236 |
| QTc interval (ms) | |||
| V5 | |||
| Pre SCB | 387±29 | 388±27 | 0.8371 |
| Post SCB | 450±43 | 424±33 | 0.0046 |
All patients had type 1 ECG spontaneously or by SCB. SCB indicates sodium channel blocker; SD, sudden death; VTA, ventricular tachyarrhythmia; VT/VF, ventricular tachycardia/ventricular fibrillation.
a
P value: comparison of ECG parameters in patients with and without pilsicainide‐induced VTAs.