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. 2018 May 2;7(10):e008807. doi: 10.1161/JAHA.118.008807

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Current‐voltage (I–V) curve for ICaL density obtained using patch clamping (C). [Ca²⁺]_i transients measured by confocal microscopy (A, B, D through F). Representative images by flat scanning (A) and line scanning (B upper) and representative curve graph of [Ca²⁺]_i transients (B bottom). The mean magnitudes of [Ca²⁺]_i transients during 1 Hz (E) or 2 Hz (F) field stimulation and comparison of them (D). Data are presented as mean±SD. *Compared with the control group P<0.05. ^#Compared with DM group P<0.05. DM indicates diabetes mellitus; NS, not significant.