Table 4.

Stratified Analysis of Risk of Progressive Renal Dysfunction in Patients Grouped by the Presence of Diabetes Mellitus, Proteinuria, CKD, CAD, and Heart Failure

Subgroup (Events/Subjects)	Log Corin		Log Corin		P for Interaction
	Crude HR (95% CI)	P Value	Adjusted HR (95% CI)a	P Value
Overall (44/401)	0.17 (0.09–0.32)	<0.001	0.23 (0.12–0.44)	<0.001
Diabetes mellitus					0.875
Yes (21/133)	0.15 (0.04–0.55)	0.004	0.11 (0.03–0.39)	0.001
No (23/268)	0.16 (0.07–0.37)	<0.001	0.26 (0.09–0.75)	0.013
Proteinuria					0.842
Yes (21/80)	0.17 (0.05–0.53)	0.003	0.12 (0.03–0.40)	0.001
No (23/321)	0.18 (0.07–0.45)	<0.001	0.29 (0.11–0.77)	0.013
CKD					0.280
Yes (22/105)	0.19 (0.09–0.41)	<0.001	0.23 (0.10–0.51)	<0.001
No (22/296)	0.35 (0.06–2.07)	0.246	1.26 (0.11–15.20)	0.855
CAD					0.467
Yes (29/243)	0.16 (0.08–0.32)	<0.001	0.24 (0.12–0.49)	<0.001
No (15/158)	0.39 (0.04–3.60)	0.405	0.49 (0.03–9.37)	0.634
Heart failure					0.641
Yes (17/73)	0.30 (0.14–0.65)	0.002	0.33 (0.15–0.76)	0.008
No (27/328)	0.14 (0.03–0.63)	0.010	0.20 (0.03–1.39)	0.103

CAD indicates coronary artery disease; CI, confidence interval; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; HR, hazard ratio.

^aAdjusted for hemoglobin, log eGFR.