Table 2.
CMBs Distributional Pattern Relevant to MCI in Patients With Hypertension
| Model 0 | Model 1 | Model 2 | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value | |
| CMB No. | ||||||
| Total No. | 2.81 (1.73–3.91) | 0.001 | 2.67 (1.35–3.75) | 0.005 | 1.66 (1.15–2.78) | 0.019 |
| 1 vs none | 1.30 (0.81–2.14) | 0.109 | 1.24 (0.75–2.08) | 0.142 | 1.09 (0.65–1.82) | 0.288 |
| 2 to 4 vs none | 1.61 (0.91–3.32) | 0.037 | 1.38 (0.71–2.94) | 0.071 | 1.14 (0.74–2.91) | 0.181 |
| ≥5 vs none | 5.47 (2.06–11.42) | <0.001 | 4.53 (1.85–11.31) | 0.004 | 2.45 (1.35–9.54) | 0.017 |
| CMB location | ||||||
| Any CMBs | 9.91 (3.14–15.71) | <0.001 | 7.17 (2.73–12.32) | 0.001 | 2.18 (1.33–4.86) | 0.024 |
| Lobar | 4.39 (2.15–9.43) | <0.001 | 3.59 (1.24–6.23) | 0.011 | 1.55 (0.81–3.22) | 0.028 |
| Deep or infratentorial | 8.12 (4.62–13.27) | <0.001 | 5.33 (2.57–10.69) | 0.006 | 2.74 (1.24–4.78) | 0.019 |
Model 0: unadjusted. Model 1: adjusted for age, sex. Model 2: adjusted for age, sex, education, diabetes mellitus, hyperlipidemia, current smoker, current drinker, blood pressure, body mass index, intima‐media thickness, presence of silent lacunar infarction, white matter hyperintensities (periventricular hyperintensities, deep white matter hyperintensities) grade, and brain atrophy. CI indicates confidence interval; CMB, cerebral microbleed; OR, odds ratio; MCI, mild cognitive impairment.