Table 1.
Baseline Characteristics of the 1122 Patients With STEMI According to Quartiles of MR‐proADM at Admission
| All (N=1122) | MR‐pro‐ADM Quartiles (nmol/L) | P Value | ||||
|---|---|---|---|---|---|---|
| 1st ≤0.52 (n=279) | 2nd 0.53 to 0.64 (n=282) | 3rd 0.65 to 0.78 (n=281) | 4th ≥0.0.79 (n=280) | |||
| Male sex, n (%) | 848 (75.6) | 233 (83.5) | 219 (77.7) | 209 (74.4) | 187 (66.8) | <0.0001 |
| Age, y | 62 (53–70) | 54 (47–62) | 58 (52–66) | 65 (55–71) | 71 (62–80) | <0.0001 |
| Medical history | ||||||
| Previous myocardial infarction, n (%) | 73 (6.5) | 14 (5.0) | 15 (15.3) | 22 (7.8) | 22 (7.9) | 0.09 |
| Congestive heart failure, n (%) | 47 (4.2) | 7 (2.5) | 5 (1.8) | 13 (4.6) | 22 (7.9) | 0.0004 |
| Previous stroke, n (%) | 49 (4.4) | 9 (3.2) | 9 (3.2) | 15 (5.3) | 16 (5.7) | 0.08 |
| Diabetes mellitus, n (%) | 110 (9.8) | 22 (7.9) | 24 (8.5) | 25 (8.9) | 39 (13.9) | 0.02 |
| Hypertension, n (%) | 450 (40.1) | 82 (29.4) | 100 (35.6) | 115 (40.9) | 153 (54.6) | <0.0001 |
| Hyperlipidemia, n (%) | 393 (35.0) | 94 (33.7) | 107 (37.9) | 93 (33.1) | 99 (35.4) | 1.0 |
| History of smoking, n (%) | 897 (80.0) | 215 (77.1) | 226 (80.1) | 230 (81.9) | 226 (80.7) | 0.24 |
| Body‐mass index, kg/m2 | 26.6 (24.2–29.6) | 26.5 (24.2–28.7) | 26.0 (23.8–29.2) | 26.6 (24.5–30.4) | 27.1 (24.4–30.2) | 0.03 |
| Multivessel disease, n (%) | 428 (38.2) | 105 (37.6) | 111 (39.4) | 97 (34.5) | 115 (41.1) | 0.67 |
| TIMI‐flow before PCI, n (%) | 0.50 | |||||
| 0 | 572 (51.0) | 145 (52.0) | 131 (46.5) | 147 (52.3) | 149 (53.2) | |
| 1 | 95 (8.5) | 24 (8.6) | 31 (11.0) | 20 (7.1) | 20 (7.1) | |
| 2 | 199 (17.7) | 49 (17.6) | 45 (16.0) | 55 (19.6) | 50 (17.9) | |
| 3 | 256 (22.8) | 61 (21.9) | 75 (26.6) | 59 (21.0) | 61 (21.8) | |
| Left ventricular ejection fraction, % | 50 (40–55) | 50 (45–55) | 50 (40–55) | 50 (40–55) | 45 (35–50) | <0.0001 |
| Clinical data at admission | ||||||
| Heart rate, bpm | 73 (61–87) | 70 (60–84) | 72.5 (61–87) | 74 (64–84) | 75 (59–92) | 0.06 |
| Systolic BP, mm Hg | 133 (118–149) | 133 (122–149) | 131 (116–149) | 134 (119–148) | 131 (115–151) | 0.29 |
| Diastolic BP, mm Hg | 82 (72–93) | 84 (76–94) | 82 (72–97) | 84 (72–93.5) | 80 (70–91) | 0.003 |
| Infarct location | 0.07 | |||||
| Anterior, n (%) | 478 (42.6) | 105 (37.6) | 139 (49.3) | 123 (43.8) | 111 (39.6) | |
| Inferior, n (%) | 595 (26.7) | 162 (58.1) | 130 (46.1) | 142 (50.5) | 161 (57.5) | |
| Posterior, n (%) | 47 (4.2) | 12 (4.3) | 12 (4.3) | 16 (5.7) | 7 (2.5) | |
| Left bundle branch block, n (%) | 2 (<1.0) | 0 (0) | 1 (<1.0) | 0 (0) | 1 (<1.0) | |
| Laboratory values | ||||||
| Baseline hs‐cTnT, ng/L | 71 (27–190) | 55 (23–146) | 68 (25–186) | 72 (29–155) | 100 (34–353) | <0.0001 |
| Peak hs‐cTnT, ng/L | 2945 (1160–6270) | 2625 (1130–5120) | 2730 (1030–6070) | 3340 (1155–6970) | 3485 (1330–7490) | 0.02 |
| eGFR, mL/min per 1.73 m2 | 91 (76–100) | 100 (93–108) | 95 (85–103) | 89 (77–97) | 69 (53–86) | <0.0001 |
| Hemoglobin, mmol/L | 8.7 (8.1–9.2) | 8.8 (8.3–9.3) | 8.8 (8.2–9.2) | 8.7 (8.2–9.2) | 8.5 (7.7–9.0) | <0.0001 |
Data are presented as median values (25th–75th percentiles) for continuous variables and as numbers (percentages) for categorical variables. Unless indicated otherwise, the laboratory values are from blood samples obtained at admission. BP indicates blood pressure; bpm, beats per minute; eGFR, estimated glomerular filtration rate; hs‐cTnT, high‐sensitivity cardiac troponin T; MR‐proADM, midregional proadrenomedullin; PCI, percutaneous coronary intervention; STEMI, ST‐segment–elevation myocardial infarction; TIMI‐flow, angiographic thrombolysis in myocardial infarction flow.