Table 4.
Crude IRs and HRs With 95% CIs of First‐Ever IS and MI From Time‐Varying Cox Models Across Categories of TPA Before and After Adjustment for CRP: The Tromsø Study (1994–2013)
| TPA | na | Events | IR (95% CI)b | Model 1 HR (95% CI)c | Model 1 +CRP HR (95% CI)c | Absolute Attenuation of HR After Inclusion of CRP in the Modeld | Attenuation of HR After Inclusion of CRP in the Model, % | Model 2 HR (95% CI)e |
|---|---|---|---|---|---|---|---|---|
| IS | ||||||||
| No plaque | 8945 | 177 | 3.1 (2.6–3.5) | Reference | Reference | … | … | Reference |
| TPA below median | 4362 | 177 | 6.2 (5.3–7.2) | 1.37 (1.11–1.69) | 1.36 (1.10–1.68) | 0.01 | 1.7 | 1.33 (1.08–1.65) |
| TPA above median | 4361 | 317 | 11.2 (10.1–12.6) | 1.93 (1.31–1.77) | 1.85 (1.53–2.24) | 0.08 | 8.6 | 1.65 (1.36–2.01) |
| MI | ||||||||
| No plaque | 8881 | 300 | 5.2 (4.7–5.9) | Reference | Reference | … | … | Reference |
| TPA below median | 4285 | 291 | 10.4 (9.3–11.7) | 1.47 (1.25–1.73) | 1.46 (1.24–1.72) | 0.01 | 2.1 | 1.31 (1.11–1.55) |
| TPA above median | 4288 | 488 | 17.7 (16.2–19.4) | 2.14 (1.84–2.49) | 2.07 (1.78–2.41) | 0.07 | 6.1 | 1.64 (1.41–1.92) |
CI indicates confidence interval; CRP, C‐reactive protein; HR, hazard ratio; IR, incidence rate; IS, ischemic stroke; MI, myocardial infarction; TPA, total plaque area.
a
Observations.
b
Crude IRs per 1000 person‐years.
c
Age as time scale, adjusted for sex.
d
Change in HR from model 1 to model 1+CRP. CRP was log transformed.
e
Age as time scale, adjusted for sex, total cholesterol, high‐density lipoprotein cholesterol, diabetes mellitus, systolic blood pressure, smoking, body mass index, lipid‐lowering medication, antihypertensive medication, and CRP (log transformed).