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. 2018 Apr 4;7(8):e008351. doi: 10.1161/JAHA.117.008351

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Effects of serum immunoglobulin G (IgG) from subjects with postural orthostatic tachycardia syndrome (POTS), subjects with vasovagal syncope (VVS), and healthy control subjects on activation of angiotensin II type 1 receptor (AT1R) in AT1R‐transfected Chinese hamster ovary cells. A, Most subjects with POTS demonstrated elevated AT1R antibodies, whereas none of these antibodies were found in the VVS and normal control groups. B, The mean activity values of AT1R antibodies were significantly higher in the POTS group than for both subjects with VVS and normal controls. No significant difference between the VVS and normal controls was observed. IgG was tested at a concentration of 0.5 mg/mL. The dashed line is the threshold derived from the mean activity values+2 SDs of the healthy controls. Values are expressed as percentage of buffer baseline. **P<0.01.