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. 2018 Apr 4;7(8):e008351. doi: 10.1161/JAHA.117.008351

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Effects of angiotensin II type 1 receptor (AT1R) blockade on immunoglobulin G–induced AT1R activation in AT1R‐transfected Chinese hamster ovary cells. A and B, The addition of the selective AT1R blocker losartan (10 μmol/L) suppressed the AT1R activity values observed in the subjects with postural orthostatic tachycardia syndrome (POTS) to control levels. Losartan produced no significant change in the AT1R activity in the control subjects. Values are expressed as percentage of buffer baseline. **P<0.01.