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Effects of serum immunoglobulin G (IgG) from patients with postural orthostatic tachycardia syndrome (POTS) on angiotensin II (Ang II) responses in Ang II type 1 receptor (AT1R)–transfected Chinese hamster ovary cells. IgG from 4 patients with POTS with positive AT1R antibodies shifted the Ang II dosage response curve to the right, indicating an inhibitory allosteric effect. Control IgG failed to alter these curves. n=4. *P<0.05, **P<0.01 vs Ang II alone.
