Table 3.
Apixaban (n=5843) | Dabigatran (n=20 079) | Rivaroxaban (n=27 777) | Warfarin (n=19 375) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Events | Crude Incidencea | Adjusted Incidenceb | Events | Crude Incidencea | Adjusted Incidenceb | Events | Crude Incidencea | Adjusted Incidenceb | Events | Crude Incidencea | Adjusted Incidenceb | |
Ischemic stroke/systemic embolism | 100 | 2.26 | 2.26 | 854 | 2.74 | 2.90 | 977 | 2.84 | 3.00 | 929 | 3.26 | 3.55 |
Ischemic stroke | 91 | 2.06 | 2.06 | 747 | 2.40 | 2.56 | 870 | 2.53 | 2.65 | 793 | 2.79 | 3.05 |
Acute myocardial infarction | 23 | 0.52 | 0.52 | 134 | 0.43 | 0.47 | 146 | 0.42 | 0.43 | 177 | 0.62 | 0.61 |
All‐cause mortality | 319 | 7.22 | 7.22 | 1575 | 5.05 | 6.69 | 2051 | 5.97 | 6.57 | 2588 | 9.09 | 10.96 |
Intracranial hemorrhage | 31 | 0.70 | 0.70 | 233 | 0.75 | 0.70 | 272 | 0.79 | 0.74 | 378 | 1.33 | 1.41 |
Major gastrointestinal bleeding | 28 | 0.63 | 0.63 | 362 | 1.16 | 1.28 | 394 | 1.15 | 1.07 | 444 | 1.56 | 1.65 |
All major bleeding | 67 | 1.52 | 1.52 | 625 | 2.01 | 2.12 | 707 | 2.06 | 1.97 | 855 | 3.00 | 3.25 |
Events divided by 100 person‐years.
Inverse probability of treatment weighted to apixaban and expressed as population average treatment rates per 100 years.