Table 3.
Intracellular cytokines—mean fluorescence intensity (MFI) data
| Arbitrary unit | Moderate HIE (n = 17) |
Severe HIE (n = 11) |
NAIS (n = 4) |
|
|---|---|---|---|---|
| MFI IL-17 / CD8 | 6 h | 1427 (661.5–2402) | 1591 (1157–7047) | 4855 (2618–8706) a, p = 0.01 |
| MFI IFN-γ / CD4 | 72 h | 455 (149.5–770) | 887 (495.5–1427) | 42.25 (28.13–438.5) a, p = 0.04; b, p = 0.01 |
| MFI IL-6 /CD8 | 72 h | 701 (364.8–1441) | 1073 (795–2017) | 646.5 (188.7–736.3) b, p = 0.03 |
| MFI IL-6 / CD8 | 1 month | 429 (101.7–617.0) | 347 (83–491) | 918.5 (638.3–1347) a, p = 0.01; b, p = 0.02 |
| MFI IL-10 / CD8 | 6 h | 1883 (512.5–5817) | 1874 (1157–3415) | 705 (280–3313) |
| MFI IL-10 / CD4 | 24 h | 674.5 (177.8–2608) | 1084 (203–1892) | 666 (242.5–1063) |
| MFI IL-10 / CD8 | 72 h | 2167 (1462–5964) | 1505 (1055–3819) | 443.5 (371–5977) |
| MFI TGF-β / CD4 | 1 week | 4620 (2654–6647) | 3129 (1238–5621) | 3260 (1452–3680) |
| MFI TGF-β / CD4 | 1 month | 811.5 (253–1740) | 634 (259–1789) | 330.5 (123–2283) |
The intracellular level of certain cytokines in T cells is shown by the MFI of each cytokine. Data are expressed as median and interquartile range; a = moderate HIE vs NAIS, p < 0.05; b = severe HIE vs NAIS, p < 0.05