Table 3.
Feature | Compared to control | |
---|---|---|
Noise-induced changes | Aging-dependent changes | |
Cognition | ||
Learning | Decreased | Decreased |
Memory | Decreased | n.s. |
Aβ amount | Increased | Increased |
Gut microbiota | ||
Alpha diversity | Decreased (n.s.) | Decreased (n.s.) |
Beta diversity | Decreased (n.s.) | Decreased (n.s.) |
PCoA | Distinct | n.s. |
Microbiota pattern | Distinct | n.s. |
Firmicutes | Increased | n.s. |
Bacteroidetes | Decreased | n.s. |
Intestinal tight junctions | ||
CLDN1 | Decreased | Decreased |
CLDN3 | Decreased | Decreased |
ZO-1 | Decreased | Decreased |
Occludin | Decreased | Decreased (n.s.) |
Brain tight junctions | ||
CLDN1 | Decreased | Decreased |
CLDN3 | Decreased (n.s.) | Decreased (n.s.) |
ZO-1 | Decreased | Decreased |
Occludin | Decreased (n.s.) | Decreased (n.s.) |
Neurotransmitters | ||
GABA | Decreased | n.s. |
5-TH | Decreased | n.s. |
Inflammation | ||
ET | Increased | Increased |
BLC | Increased | Increased |
KC | n.s. | Increased |
LIX | Increased | Increased |
MCP-5 | Decreased | n.s. |
MIP-1a | n.s. | Increased |
n.s. not significant