Table 3.
Summarized comparison of changes caused by noise exposure and aging
| Feature | Compared to control | |
|---|---|---|
| Noise-induced changes | Aging-dependent changes | |
| Cognition | ||
| Learning | Decreased | Decreased |
| Memory | Decreased | n.s. |
| Aβ amount | Increased | Increased |
| Gut microbiota | ||
| Alpha diversity | Decreased (n.s.) | Decreased (n.s.) |
| Beta diversity | Decreased (n.s.) | Decreased (n.s.) |
| PCoA | Distinct | n.s. |
| Microbiota pattern | Distinct | n.s. |
| Firmicutes | Increased | n.s. |
| Bacteroidetes | Decreased | n.s. |
| Intestinal tight junctions | ||
| CLDN1 | Decreased | Decreased |
| CLDN3 | Decreased | Decreased |
| ZO-1 | Decreased | Decreased |
| Occludin | Decreased | Decreased (n.s.) |
| Brain tight junctions | ||
| CLDN1 | Decreased | Decreased |
| CLDN3 | Decreased (n.s.) | Decreased (n.s.) |
| ZO-1 | Decreased | Decreased |
| Occludin | Decreased (n.s.) | Decreased (n.s.) |
| Neurotransmitters | ||
| GABA | Decreased | n.s. |
| 5-TH | Decreased | n.s. |
| Inflammation | ||
| ET | Increased | Increased |
| BLC | Increased | Increased |
| KC | n.s. | Increased |
| LIX | Increased | Increased |
| MCP-5 | Decreased | n.s. |
| MIP-1a | n.s. | Increased |
n.s. not significant