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. Author manuscript; available in PMC: 2018 Jun 23.
Published in final edited form as: J Med Chem. 2017 Jul 13;60(14):6364–6383. doi: 10.1021/acs.jmedchem.7b00561

Scheme 1.

Scheme 1

General Synthetic Route to Aryloxazole Analogues 7a

aReagents and conditions: (a) HCl(g) (4 M in dioxane), AcOH, 0 °C to rt; (b) POCl3, DCE, reflux; (c) KOH, EtOH, isonipecotic acid, rt; (d) HOBt hydrate, DMAP, diisopropylcarbodiimide, DCM, rt or HOBt hydrate, diisopropylcarbodiimide, MeCN, μW irradiation, 100 °C, 10 min.