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. Author manuscript; available in PMC: 2018 Jun 23.
Published in final edited form as: J Med Chem. 2017 Jul 13;60(14):6364–6383. doi: 10.1021/acs.jmedchem.7b00561

Scheme 2.

Scheme 2

Synthetic Route to Thiazole Analogue 13a

aReagents and conditions: (a) iPrOH, μW irradiation, 120 °C, 1 h, 65% yield; (b) NCS, MeCN, 60 °C, 2 h, 82% yield; (c) KOH, EtOH, isonipecotic acid, rt, 78% yield; (d) HOBt hydrate, diisopropylcarbodiimide, MeCN, μW irradiation, 100 °C, 10 min, 45% yield.