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Representative Synthetic Route to Desmethyloxazole Analogues; Synthesis of 18aa
aReagents and conditions: (a) toluene, 140 °C, 5 h, 57% yield; (b) KOH, EtOH, isonipecotic acid, rt, 93% yield; (d) HOBt hydrate, DMAP, diisopropylcarbodiimide, DCM, rt, 60% yield.
