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HCV Inhibition and Cytotoxicity of 2-Thiophene-Containing Benzofuran Analogs
| Cmpd |
|
HCV-Luc EC50 (µM) |
ATPlite CC50 (µM) |
Selective Index (SI) |
|
|---|---|---|---|---|---|
| R2 | R3 | ||||
| 3{1} |
|
|
>31.6 | > 100 | N.A. |
| 3{2} |
|
|
> 31.6 | 34.20 | < 1 |
| 3{3} |
|
|
2.44 | 43.60 | 18 |
| 3{4} |
|
|
0.177 (n=3) | > 100 | > 568 |
| 3{5} |
|
|
11.7 | > 100 | > 9 |
| 3{6} |
|
|
8.56 | > 100 | > 12 |
| 3{7} |
|
|
1.52 | 26.40 | 17 |
