Table 3.
SCN2A homologues in model organisms
| Species | Number of NaV channel isoforms | Closest human NaV1.2homologue | Percent homology to human NaV1.2 |
|---|---|---|---|
| Yeast (Saccharomyces cerevisiae) | 0 | N/A | N/A |
| Worm (Caenorhabditis elegans) | 0 | N/A | N/A |
| Fruit Fly (Drosophila melanogaster) | 2 | Para / Para | 70% |
| Zebrafish (Danio rerio) | 4x2* | Scn1lab / Nav1.1Lb | 86% |
| Frog (Xenopus Tropicalis) | 6 | Scn2a / Nav1.2 | 85% |
| Chicken (Gallus gallus) | 9 | SCN2A / NaV1.2 | 93% |
| Mouse (Mus musculus) | 10 | Scn2a / NaV1.2 | 98% |
| Rat (Rattus norvegicus) | 10 | Scn2a / NaV1.2 | 98% |
| Rhesus (Macaca mulatta) | 10 | Scn2a / NaV1.2 | 99.9% |
| Human (Homo sapiens) | 10 | SCN2A / NaV1.2 | 100% |
*
Zebrafish have two copies of each of these four NaV channels due to relatively recent genome duplication.