Table 3.
Species | Number of NaV channel isoforms | Closest human NaV1.2homologue | Percent homology to human NaV1.2 |
---|---|---|---|
Yeast (Saccharomyces cerevisiae) | 0 | N/A | N/A |
Worm (Caenorhabditis elegans) | 0 | N/A | N/A |
Fruit Fly (Drosophila melanogaster) | 2 | Para / Para | 70% |
Zebrafish (Danio rerio) | 4x2* | Scn1lab / Nav1.1Lb | 86% |
Frog (Xenopus Tropicalis) | 6 | Scn2a / Nav1.2 | 85% |
Chicken (Gallus gallus) | 9 | SCN2A / NaV1.2 | 93% |
Mouse (Mus musculus) | 10 | Scn2a / NaV1.2 | 98% |
Rat (Rattus norvegicus) | 10 | Scn2a / NaV1.2 | 98% |
Rhesus (Macaca mulatta) | 10 | Scn2a / NaV1.2 | 99.9% |
Human (Homo sapiens) | 10 | SCN2A / NaV1.2 | 100% |
Zebrafish have two copies of each of these four NaV channels due to relatively recent genome duplication.