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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Trends Neurosci. 2018 May 2;41(7):457–469. doi: 10.1016/j.tins.2018.04.002

Figure 2. The Effect of Poly(A) Tail on the Subcellualr Localization and Toxicity of Expanded G4C2 Repeats.

Figure 2

In (G4C2)n-polyA models (top panel), repeat RNA is transported to the cytoplasm, where it is translated into DPR proteins. Diffuse G4C2 RNA is detected mostly in the cytoplasm, and higher toxicity correlate with high levels of DPR protein production. In intronic (G4C2)n models (bottom panel), repeat RNA accumulates in the nucleus as RNA foci and less DPR protein is produced. Thus, only low levels of toxicity are observed.