Table 1.
Demographic and clinical characteristics of young adults with a history of pediatric chronic kidney disease at time of first GFR after age 18 years. Median [interquartile range] or % (frequency).
| Participants contributing estimated GFR n= 219 |
Participants contributing iohexol GFR n= 187 |
|
|---|---|---|
| Age | 18.5 [18.2, 18.9] | 18.7 [18.3, 19.3] |
| Female sex | 41% (89) | 42% (78) |
| African American race | 21% (46) | 19% (36) |
| Body size | ||
| Height, m | 1.69 [1.61, 1.77] | 1.69 [1.61, 1.77] |
| Weight, kg | 68 [57, 84] | 67 [57, 84] |
| Body mass index, kg/m2 | 24 [20, 29] | 23 [20, 29] |
| Body surface area, m2 | 1.8 [1.6, 2.0] | 1.8 [1.6, 2.0] |
| CKD characteristics | ||
| Non - glomerular form of CKD | 63% (137) | 61% (115) |
| CKD onset at birth | 51% (111) | 51% (93) |
| CKD onset > 0 and ≤ 5 years old | 12% (26) | 13% (23) |
| CKD onset > 5 and ≤ 10 years old | 10% (21) | 11% (20) |
| CKD onset > 10 and < 16 years old | 27% (58) | 26% (48) |
| Urine protein:creatinine, mg/mg Cr | 0.7 [0.2, 1.6] | 0.7 [0.2, 1.6] |
| Nephrotic range proteinuria | 19% (40) | 16% (29) |
| (> 2 mg/mg Cr) | ||
| Biomarkers of kidney function | ||
| Serum creatinine, mg/dL | 1.6 [1.2, 2.2] | 1.6 [1.2, 2.1] |
| Height/Serum creatinine, m/mg/dL | 1.0 [0.8, 1.4] | 1.1 [0.8, 1.4] |
| Cystatin c, mg/L (IFCC calibrated) | 1.6 [1.2, 2.3] | 1.6 [1.2, 2.2] |
| Blood urea nitrogen, mg/dL | 23 [17, 33] | 24 [17, 33] |
| Number of GFR observationsa | ||
| One observation | 32% (71) | 63% (118) |
| Two observations | 26% (56) | 26% (48) |
| Three or more observations | 42% (92) | 11% (21) |
| Total number of observations | 548 | 279 |
a
By study design, estimated GFR was measured annually and iohexol-based GFR was measured every two years.