Figure 2.

SHP2 plays a key role in HSC differentiation and self-renewal. Kit, an important surface marker of hematopoietic cells, plays a pivotal role in HSC self-renewal. Kit-SHP2-GATA2 loop positively regulates HSC stemness. In addition, ERK may be functioned as a downstream effector of SHP2 in HSC self-renewal. During HSC differentiation, SHP2/AKT may be involved in the myeloid differentiation and SHP2/GATA1 signaling regulates HSC differentiation into erythroid cells. Besides, SHP2/JAK/STAT5 signaling is responsible for HSC proliferation.