Table 3.
Cxs/Cx-channels in BBB in CNS pathology.
| CNS pathology | Cxs/Cx channel remodeling | BBB dysfunction | Reference |
|---|---|---|---|
| MOG-induced EAE mouse model | Deletion of both Cx30 and Cx43 | None | [126] |
| Carrageenan-induced inflammatory pain rat model | Not mentioned | Increased expression of ZO-1 in TJs and permeability of the BBB | [92] |
| MCAO mouse model | Cx43 +/−, GJIC reduction | Weakened barrier function of BBB and exacerbated ischemic injury | [98] |
| Age-related neurodegenerative disease mouse model | Increased expression and relocalization of Cx43 in ECs | An increase in the permeability of the BBB without change of ZO-1 | [108] |
| 4-AP-induced epilepsy rat model | Gradually elevated expression of Cx43 and GJIC remodeling | Not mentioned | [118] |
| HIV-infected neuroAIDS macaque model | HIV amplified by GJs | Compromised BBB integrity | [123] |
Cx: connexin; TJs: tight junctions; GJs: gap junctions; ZO: Zona occludin; GJIC: gap junction intercellular communication; BBB: brain-blood barrier; 4-AP: 4-aminopyridine.