Table 1.
Inhibitory effects of the major compounds from Ampelopsis brevipedunculata on IL-6/STAT3 activation.
| Compound | IC50 (μM) | Compound | IC50 (μM) |
|---|---|---|---|
| Betulin (1) | 3.12 ± 0.31 | Ethyl gallate (10) | 44.13 ± 3.16 |
| Betulinic acid (2) | 6.98 ± 0.34 | Ethyl gallyl 4-O-α-D-glucopyranoside (11) | 22.85 ± 0.74 |
| β-Sitosterol (3) | > 50 | Syringic acid (12) | 15.82 ± 4.70 |
| β-Sitosterol glucoside (4) | > 50 | Benzyl 6′-O-galloyl-β-D-glucopyranoside (13) | 4.99 ± 2.02 |
| Aromadendrin (5) | 49.73 ± 10.15 | Ellagic acid (14) | 4.85 ± 1.73 |
| 3-O-Glycoside-aromadendrin (6) | > 50 | 3′-O-Methylellagic acid 4-O-α-L-rhamnopyranoside (15) | > 50 |
| Catechin (7) | > 50 | 4′-O-(β-D-Glucopyranosyl)-3,3′4-tri-O-methylellagic acid (16) | > 50 |
| Gallic acid (8) | 27.30 ± 3.58 | Resveratrol (17) | 21.18 ± 1.10 |
| Vanillic acid (9) | > 50 | Genisteina | 13.60 ± 0.36 |
a Genistein was used as the positive control.