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. Author manuscript; available in PMC: 2018 Jun 24.
Published in final edited form as: Cell Rep. 2018 May 22;23(8):2264–2272. doi: 10.1016/j.celrep.2018.04.081

Figure 1. DLS Photosilencing Expedites Early Discriminated Choice Learning.

Figure 1

(A–C) Touchscreen visual discrimination training (A) increased correct responding (F2,50 = 185.25, p < 0.01, n = 26) (B) and decreased error rates (F2,50 = 161.06, p < 0.01) (C).

(D) GFP-labeled DLS AAV-expression. EP, endopeduncular nucleus; GPe, external globus pallidus; SNr, substantia nigra reticulata.

(E) Green light reduced DLS neuronal activity ex vivo (t[80] = 4.68, p < 0.01, n = 7).

(F and G) DLS photosilencing did not affect open-field locomotion (F) or real-time place preference (G).

(H–L) DLS photosilencing (H) increased early-stage percentage correct responding (t[14] = 2.40, p = 0.05, n = 7–9) (I), decreased errors (t[14] = 2.91, p < 0.01) (J), and increased percentage win-stay (t[14] = 2.92, p < 0.05) (K) and percentage lose-shift (t[14] = 2.96, p < 0.05) (L) behavior.

*p < 0.05. Data are mean ± SEM.