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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Neurotoxicology. 2018 Mar;65:68–84. doi: 10.1016/j.neuro.2018.01.009

Figure 9. Temporal development of HCA-induced selective decreases in dopaminergic neurite lengths.

Figure 9

Decreased dopaminergic neurite lengths were detected in cultures exposed to PhIP (A), MeIQ (C), and harmane (E) at 1 µM (24 – 72 h) (n = 519 – 834 TH+ neurites/group analyzed). Non-dopaminergic neurites are not affected at the tested dose at all time-points (B,D,F) (n = 859 – 1204). Cells were stained for TH (green) to identify dopamine neurons and MAP2 (red) to identify all neurons. Data presented as the mean ± SEM; general linear model with Dunnett’s post-hoc test, **p<0.01, ***p< 0.001 compared to control. n = total number of neurites measured from 3 different experiments.