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. Author manuscript; available in PMC: 2019 Jun 22.
Published in final edited form as: Circ Res. 2018 May 15;123(1):86–99. doi: 10.1161/CIRCRESAHA.118.312981

Figure 6. Vegfa-Vegfr2 signaling regulates BBB integrity.

Figure 6

A, Images of cerebral sections of 10-kDa Dextran-tracer injected mice after capillary labelling with lectin. B,C, Immunostaining for tdTomato and TER-119 (B) or Glut1 (C) on brain sections shows a significant leakiness of blood cells (arrowheads). D, Immunostaining for tdTomato and PLVAP (a component of endothelial fenestration) shows increased PLVAP expression in the mutant E, Immunostaining for tdTomato and CTNNB1 on brain sections shows reduced CTNNB1 expression in the mutant. Scale bars, 100 µm. Each image is representative of 5 individual samples.