Table 1.
Multivariable model of factors associated with incidence of scar through year 5
| Baseline Characteristics | Eyes at Risk, N | Scar, n (%) | Hazard Ratio (95% CI) | P-value |
|---|---|---|---|---|
| Drug group | 0.23 | |||
| Ranibizumab | 526 | 253 (48%) | 1.00 | |
| Bevacizumab | 484 | 256 (53%) | 1.15 (0.92, 1.44) | |
| Dosing regimen during first 2 years | 0.17 | |||
| Pro re nata (PRN) for 2 years | 504 | 248 (49%) | 1.00 | |
| Switched from monthly to PRN at 1 year | 253 | 138 (55%) | 1.29 (0.98, 1.69) | |
| Monthly for 2 years | 253 | 123 (49%) | 1.02 (0.77, 1.35) | |
| Baseline VA in fellow eye | 0.04 | |||
| 20/50 or worse | 308 | 146 (47%) | 1.00 | |
| 20/25-20/40 | 398 | 186 (47%) | 0.97 (0.74, 1.28) | |
| 20/20 or better | 304 | 177 (58%) | 1.34 (1.00, 1.79) | |
| Lesion type | <0.001 | |||
| Occult only | 614 | 224 (36%) | 1.00 | |
| Minimally classic | 175 | 121 (69%) | 2.74 (2.04, 3.69) | |
| Predominantly classic | 221 | 164 (74%) | 4.49 (3.34, 6.04) | |
| Hemorrhage associated with the lesion | <0.001 | |||
| None | 401 | 186 (46%) | 1.00 | |
| <=1 Disc Area | 519 | 259 (50%) | 0.92 (0.73, 1.18) | |
| >1 Disc Area | 90 | 64 (71%) | 2.28 (1.49, 3.47) | |
| Retinal thickness at foveal center (μm) | <0.001 | |||
| <120 | 103 | 44 (43%) | 1.00 | |
| 120 to 212 | 541 | 252 (47%) | 1.50 (1.00, 2.24) | |
| >212 | 366 | 213 (58%) | 2.58 (1.69, 3.94) | |
| Subretinal fluid thickness at foveal center (μm) | 0.01 | |||
| =0 | 668 | 339 (51%) | 1.00 | |
| >0 to <=25 | 83 | 49 (59%) | 1.84 (1.21, 2.80) | |
| >25 | 259 | 121 (47%) | 1.31 (0.97, 1.75) | |
| Subretinal tissue complex thickness at foveal center (μm) | <0.001 | |||
| >0 to <=75 | 246 | 89 (36%) | 1.00 | |
| >75 to <=160 | 244 | 130 (53%) | 1.74 (1.23, 2.46) | |
| >160 to <=275 | 257 | 143 (56%) | 1.98 (1.38, 2.82) | |
| >275 | 263 | 147 (56%) | 2.64 (1.81, 3.84) | |
| Retinal pigment epithelial elevation | 0.002 | |||
| Yes | 878 | 419 (48%) | 1.00 | |
| No | 132 | 90 (68%) | 1.71 (1.21, 2.41) | |
| Subretinal hyperreflective material | <0.001 | |||
| No | 236 | 71 (30%) | 1.00 | |
| Yes | 774 | 438 (57%) | 1.72 (1.25, 2.36) |
P value from Cox proportional hazards model.
*
51 patients were not included in the multivariate model because of missing value in one or more of the following variables: Lesion type, Hemorrhage associated with the lesion, Retinal thickness at foveal center (μm), Subretinal fluid thickness at foveal center (μm), Subretinal tissue complex thickness at foveal center (μm), Retinal pigment epithelial elevation, Subretinal hyperreflective material. VA = Visual acuity