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Histology score of colitis in mice not given DSS or indirubin (control), given DSS but not indirubin, or given DSS and indirubin. Mice were administered indirubin (0.05 μg/g/day, p.o.) in their diet. (A) Acute-colitis model on day-6. (B) Chronic-colitis model on day-42. The large intestine was isolated, and morphologic analyses undertaken. The histopathologic severity of colitis was calculated.
DSS, dextran sulfate sodium; N.S, not significant; p.o., per os.
