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IL-15 induces loss of CD28 by naive CD8+ T cells. Fluorescence-activated cell sorting-sorted naive CD8+CD45RO−CCR7+CD28+ T cells were cultured in the presence of IL-15 (50 ng/ml). Directly after sorting and after 5, 10, and 15 days of culture, expression of (A) CD45RO, (B) CCR7, and (C,D) CD28 was assessed. MFI = median fluorescence intensity. Significance (*p < 0.05, **p < 0.01, ***p < 0.001) is depicted. N = 6.
