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. 2018 Jun 18;9:1345. doi: 10.3389/fimmu.2018.01345

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Copyright © 2018 Haspels, Rahman, Joseph, Gras Navarro and Chekenya.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differentiation and reversal of differentiation. Neurospheres (Nsp), differentiated to adherent cells (Diff) in 10% serum-containing medium and reverted back to a de-differentiated state (Diff-Nsp) after 14 days in stem-cell medium, (A) BG5 and (B) BG7 primary tumors. (C) Bar graph showing Nsp diameter in Nsp (black) and Diff-Nsp (gray) in BG5 and BG7 glioblastoma (GBM) cells. Data represent mean ± SD of n = 3 independent experiments per GBM patient-derived line. One-way ANOVA, Bonferroni’s multiple comparison test, ****P < 0.0001. Western blot showing glial acidic fibrillary protein and GAPDH in Nsp, differentiated, and de-differentiated Nsp (D) BG5 and (E) BG7 GBM cells.