Table 2.
Biomarkers of the three groups.
| Groups (number) | Control (39) | aMCI (25) | AD (16) | aFbChi | P |
|---|---|---|---|---|---|
| PiB+/PiB- | 11/28 | 17/8 | 15/1 | 22.577b | <0.001 |
| PiB+ of E4- (%) | 6 (20) | 7 (50) | 6 (100) | 16.18b | <0.001 |
| PiB+ of E4+ (%) | 5 (55.6) | 10 (90.9) | 9 (88.9) | 4.5b | =0.105 |
| mcSUVR | 1.01 ± 0.66 | 1.21 ± 0.23 | 1.47 ± 0.27 | 38.199a | <0.001 |
| mCT (mm) | 2.65 ± 0.19 | 2.52 ± 0.18 | 2.39 ± 0.14 | 13.81a | <0.001 |
| Plasma Aβ40 (pg/ml) | 59.2 ± 11.1 | 41.5 ± 3.9 | 39.5 ± 5.8 | 47.634a | <0.001 |
| Plasma Aβ42 (pg/ml) | 16.1 ± 1.8 | 17.0 ± 2.0 | 19.0 ± 2.7 | 11.192a | <0.001 |
| Plasma Tau (pg/ml) | 14.3 ± 6.4 | 29.7 ± 8.7 | 39.4 ± 5.8 | 61.535a | <0.001 |
aAnalyses of variance. bPearson’s Chi-square test. aMCI, amnesic mild cognitive impairment; AD, Alzheimer’s disease; PiBC+/PiB-, ratio between subjects with PiB-PET positivity and negativity; TMSE, Taiwanese Mental State Examination; mCT, mean thickness of all cortical areas in millimeters; mcSUVR, mean SUVR of all cortical regions; E4+, ApoE4 carrier; E4-, non-ApoE4 carrier.