Skip to main content
. 2018 Jun 18;8:218. doi: 10.3389/fonc.2018.00218

Figure 1.

Figure 1

Histamine dihydrochloride (HDC)-induced differentiation of leukemic cells is NOX2-dependent. (A) FACS-plots showing NOX2 and H2R expression on wild-type (WT) and NOX2-KO PLB-985 cells. Expression of CD11b (B,C), FPR1 (D), and FPR2 (E) on WT and NOX2-KO PLB-985 cells cultured in the presence or absence of HDC or dimethyl sulfoxide (DMSO) as determined by flow cytometry. (F) FACS-plot showing NOX2 and H2R expression by OCI-AML3 cells. Expression of CD11b (G), CD14 (H), FPR1 (I), and FPR2 (J) on OCI-AML3 cells cultured in the presence or absence of HDC or DMSO. Abbreviations: MFI, median fluorescence intensity. ANOVA; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.