Table 2.
A summarizing PSCs biomarkers associated with pancreatic cancer promotion/invasiveness and suppression.
| Year | PSCs biomarkers | Function |
|---|---|---|
| 2009 | S100A4 | S100A4 is key component of the pancreatic tumor stroma. |
| 2010 | CD10 | CD10+ PSCs enhance the progression of pancreatic cancer. |
| 2012 | CD271 | CD271+ subpopulation of PSCs correlates with prognosis of pancreatic cancer and is regulated by interaction with cancer cells. |
| 2014 | Palladin | Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts. |
| 2016 | P2X7R | P2X7R expressed in tumor and PSCs, which is related to PSCs number/activity, as well as collagen deposition. |
| 2017 | HGF | HGF show the functional heterogeneity in tumor-derived human PSCs, which implicated the mitogenic signaling and migration in pancreatic cancer. |
| 2017 | Cadherin-11 | Cadherin-11 is a cell surface marker up-regulated in activated PSCs and is involved in pancreatic cancer migration. |
| 2017 | Kindlin-2 | Kindlin-2 in PSCs promotes the progression of pancreatic cancer. |
| 2017 | PAK1 | Inhibition of PAK1 suppresses PSCs activation and increases survival of mice with pancreatic cancer. |
| 2017 | iCAFs and myCAFs (αSMA and IL-6) | CAFs coexist as two mutually exclusive and reversible subtypes: iCAFs and myCAFs, which have different location in pancreas and hold different function. |