Table 5. Changes of total cholesterol from baseline during letrozole treatment with intention-to-treat population.
| Total cholesterol | Baseline | Months | p-value | ||
|---|---|---|---|---|---|
| 12 | 24 | 36 | |||
| N | 881 | 778 | 672 | 281 | 0.0423* |
| Mean (mg/dL) | 198.9 | 202.1 | 201.1 | 203.7 | 0.0211† |
| SD (mg/dL) | 35.9 | 35.4 | 35 | 31.4 | |
| p-value‡ | - | 0.0130 | 0.0391 | 0.0142 |
SD=standard deviation.
*For an equality of mean total cholesterol across visits using generalized estimating equation (GEE); †For a linear trend test of mean total cholesterol across visits within GEE analysis; ‡For comparisons of mean total cholesterol change from baseline to each of following visits using contrasts within GEE.