Table S4.

Age-standardized prevalence of baseline comorbidities in adult patients with psoriasis by severity of the disease and sex

Comorbidities by sex	Mild psoriasisa			Moderate-to-severe psoriasisb			Severe psoriasisc
	No.	%	95% CI	No.	%	95% CI	No.	%	95% CI
Male	35850			5605			988
Female	34946			6314			1159
Cardiovascular diseases
Myocardial infarction
Male	1357	3.40	3.21–3.59	185	3.55	3.08–4.07	19	2.73	1.80–3.95
Female	713	1.68	1.54–1.82	86	1.35	1.08–1.66	8	1.21	0.66–2.02
Angina pectoris
Male	1278	3.24	3.06–3.43	166	3.19	2.75–3.69	28	3.03	2.06–4.30
Female	834	1.94	1.80–2.09	141	2.20	1.85–2.59	15	1.64	0.99–2.55
Peripheral arterial diseased
Male	833	2.11	1.97–2.27	134	2.62	2.22–3.08	12	8.10	6.47–9.97
Female	616	1.44	1.32–1.57	79	1.17	0.92–1.47	9	0.69	0.30–1.36
Atrial fibrillation
Male	1521	4.04	3.83–4.25	193	3.87	3.82–4.41	32	4.05	2.91–5.47
Female	933	2.28	2.13–2.45	137	2.55	2.18–2.94	12	0.87	0.41–1.58
Heart failure and hypertensive diseases
Male	1664	4.45	4.24–4.67	215	4.17	3.67–4.73	35	4.05	2.91–5.47
Female	1249	3.10	2.92–3.28	180	3.33	2.90–3.80	24	5.26	4.05–6.71
Essential hypertensiond
Male	12549	30.27	29.79–30.74	1839	31.94	30.72–33.17	302	33.50	30.56–36.54
Female	12526	29.56	29.08–30.04	2344	33.39	32.22–34.56	363	37.62	34.82–40.48
Cerebrovascular diseases
Stroke
Male	1116	2.96	2.78–3.14	123	2.46	2.07–2.90	8	0.80	0.35–1.59
Female	802	1.95	1.81–2.10	115	1.92	1.59–2.29	13	1.29	0.72–2.13
Transient ischemic attack
Male	347	0.91	0.82–1.02	42	0.89	0.66–1.17	2	0.10	0.00–0.06
Female	265	0.64	0.55–0.72	39	0.63	0.45–0.86	7	0.78	0.36–1.47
Metabolic diseases
Diabetesd
Male	3468	8.35	8.06–8.64	479	8.00	7.30–8.73	76	9.92	8.13–11.95
Female	2820	6.90	6.64–7.18	539	8.16	7.49–8.86	86	10.70	8.98–12.62
Treatment with statins
Male	6465	15.08	14.71–15.45	896	15.25	14.32–15.45	124	20.44	17.97–23.10
Female	5339	16.84	16.45–17.24	918	13.60	12.77–14.48	117	16.48	14.39–18.74
Obesity
Male	505	1.27	1.16–1.39	96	1.53	1.23–1.89	15	1.11	0.56–1.98
Female	914	2.76	2.59–2.93	198	3.33	2.90–3.80	41	2.76	1.90–3.88
Other disease
Chronic obstructive pulmonary disease
Male	1126	3.06	2.91–3.27	209	4.23	3.72–4.79	38	4.15	2.99–5.59
Female	1589	4.12	3.92–4.34	311	4.88	4.36–5.43	69	5.18	3.97–6.61

Notes:

^aTopical treatment with calcipotriol or calcipotriol combinations.

^bNon-biological systemic treatment with methotrexate, cyclosporine, acitretin and phototherapy.

^cBiological treatment with adalimumab, etanercept, infliximab, efalizumab, ustekinumab, certolizumab, golimumab.

^dData obtained from both Swedish National Patient Register and Prescribed Drug Register (Table S3).