Table 2.
General Linear Model Results for Individual Regions in Three Groups
| NAA | Cho | |||
|---|---|---|---|---|
| Group | Post-Acute | Chronic | Post-Acute | Chronic |
| Temporal | ns | ns | p < 0.01 | ns |
| 1 | 13890 (688) | 13445 (321) | 2426 (110) | 2120 (77) |
| 2 | 14908 (743) | 14118 (347) | 2426 (119) | 2262 (83) |
| 3 | 14179 (441) | 13959 (206) | 2160 (71) | 2138 (49) |
| Parietal | ns | ns | p < 0.01 | p < 0.05 |
| 1 | 13931 (543) | 12589 (363) | 2005 (88) | 1734 (58) |
| 2 | 14120 (587) | 13955 (392) | 2170 (95) | 1914 (63) |
| 3 | 13527 (349) | 13433 (233) | 1755 (57) | 1775 (37) |
| Occipital | ns | ns | p < 0.01 | ns |
| 1 | 14115 (617) | 13592 (359) | 1726 (96) | 1529 (67) |
| 2 | 14015 (667) | 14388 (387) | 1904 (104) | 1649 (73) |
| 3 | 14225 (396) | 13739 (230) | 1523 (62) | 1515 (43) |
| Frontal | ns | ns | p < 0.01 | p < 0.05 |
| 1 | 13537 (533) | 12742 (326) | 2304 (95) | 2048 (61) |
| 2 | 14489 (575) | 14005 (352) | 2554 (102) | 2277 (66) |
| 3 | 13425 (342) | 13356 (209) | 2045 (61) | 2101 (39) |
| Body | ns | p < 0.05 | p < 0.05 | p = 0.06 |
| 1 | 12934 (612) | 12366 (724) | 2566 (157) | 2074 (512) |
| 2 | 14925 (661) | 16383 (782) | 2903 (170) | 3841 (553) |
| 3 | 14233 (393) | 14418 (464) | 2416 (101) | 2500 (329) |
| Genu | p < 0.05 | ns | ns | p = 0.06 |
| 1 | 11253 (1007) | 9927 (1234) | 3294 (245) | 2355 (606) |
| 2 | 11086 (1087) | 14675 (1333) | 2949 (245) | 4518 (655) |
| 3 | 13441 (646) | 12479 (792) | 2689 (157) | 2763 (389) |
| Splenium | p < 0.05 | ns | ns | p = 0.09 |
| 1 | 13271 (413) | 14664 (1870) | 2495 (89) | 1929 (961) |
| 2 | 13553 (446) | 19317 (2020) | 2326 (96) | 4580 (1038) |
| 3 | 15135 (265) | 14958 (1200) | 2055 (57) | 2013 (616) |
| Hippocampus | ns | ns | ns | ns |
| 1 | 12756 (915) | 16006 (1115) | 2751 (222) | 3328 (706) |
| 2 | 14930 (988) | 16269 (1205) | 3108 (239) | 4495 (763) |
| 3 | 14917 (587) | 14687 (716) | 2884 (142) | 2938 (453) |
| Cerebellum | p < 0.05 | p < 0.01 | ns | p < 0.01 |
| 1 | 12669 (478) | 12074 (563) | 3228 (171) | 2797 (175) |
| 2 | 14456 (516) | 13964 (609) | 3499 (184) | 3260 (189) |
| 3 | 14317 (307) | 14245 (362) | 3541 (109) | 3501 (112) |
NAA, N-acetylaspartate; Cho, choline.
Group 1: Slow interhemispheric transfer time (IHTT) traumatic brain injury (TBI); Group 2: Normal IHTT TBI; Group 3: healthy control. Ns, overall general linear model not statistically significant. Means (in generic institutional values per Maudsley, 200630) and standard deviations (in parentheses) for each metabolite by time point and by group. Statistically significant pairwise differences are discussed in the text section Combined Lobar and Combined CC Regions.