FIG. 3.

Ex vivo 7 Tesla magnetic resonance imaging (MRI) reveals focal lesions not detected by in vivo 3 Tesla MRI. Axial T2*, proton density (PD), and flash20 images synthesized from the multi-echo flash sequence are shown at the level of the superior border of the thalamus. These three datasets reveal two lesions that were not visualized on the in vivo MRI dataset (lesions 3 and 4) and confirm the presence of a lesion that was seen in vivo (lesion 2). Lesion 2 is a periventricular hyperintensity in the frontal lobe, suggesting leukoaraiosis. Lesion 3 is a curvilinear hypointensity that traverses the superficial layers of cerebral cortex in the frontal operculum, suggesting hemosiderin deposition. Lesion 4 is a punctate hyperintensity in the periventricular white matter of the occipital lobe, consistent with leukoaraiosis or possibly chronic traumatic axonal injury. Zoomed views of each lesion are shown on the inset panels, with red arrows indicating the lesions. Color image is available online at www.liebertpub.com/neu