FIG. 5.

Correlative analysis of 7 Tesla ex vivo magnetic resonance imaging (MRI) and histopathology for the curvilinear cortical lesion. Zoomed views of axial, sagittal and coronal flash20 images synthesized from the 7 Tesla multi-echo flash sequence reveal a curvilinear hypointense signal abnormality (red arrows) in the subpial region of the frontal operculum. Hematoxylin and eosin (H + E) staining of this region revealed atherosclerosis of a vessel within the subarachnoid space. Staining with glial fibrillary acidic protein (GFAP) and Perls' iron stain revealed gliosis and hemosiderin deposition, respectively, in the underlying cerebral cortex. The inset in the bottom right panel shows a high-powered view of hemosiderin-containing microglia. These findings suggest the possibility that a healed contusion accounts for the signal abnormality seen on ex vivo MRI. Color image is available online at www.liebertpub.com/neu