Table 6.
Muscle relaxant activity of crude extract and its fractions of Hypochaeris radicata. The values are presented as percentage ± SEM for each animal (n = 6).
| Groups | Dose (mg/kg) | Inclined plan test (%) | Traction test (%) | ||||
|---|---|---|---|---|---|---|---|
| 30 min | 60 min | 90 min | 30 min | 60 min | 90 min | ||
| Distilled water | 10 ml | 0 ± 0.00 | 0 ± 0.00 | 0 ± 0.00 | 0 ± 0.00 | 0 ± 0.00 | 0 ± 0.00 |
|
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| Diazepam | 1 | 100 ± 0.00 | 100 ± 0.00 | 100 ± 0.00 | 100 ± 0.00 | 100 ± 0.00 | 100 ± 0.00 |
|
| |||||||
| Crude extract | 25 | 1.44 ± 0.56 | 2.55 ± 0.77 | 3.21 ± 0.55 | 1.48 ± 0.56 | 2.53 ± 0.64 | 4.31 ± 0.50 |
| 50 | 1.87 ± 0.57 | 4.18 ± 0.69 | 4.20 ± 1.00 | 1.84 ± 0.60 | 3.56 ± 0.69 | 5.10 ± 0.70 | |
| 100 | 3.50 ± 0.58 | 4.97 ± 0.88 | 7.00 ± 1.18 | 3.65 ± 0.63 | 4.70 ± 0.60 | 7.01 ± 1.14 | |
|
| |||||||
| n-Hexane fraction | 25 | 1.25 ± 0.50 | 3.00 ± 0.55 | 3.24 ± 0.66 | 1.30 ± 0.56 | 3.25 ± 0.55 | 3.78 ± 0.60 |
| 50 | 2.57 ± 0.70 | 4.10 ± 0.97 | 4.33 ± 0.88 | 2.68 ± 0.73 | 4.27 ± 0.95 | 4.76 ± 0.99 | |
| 100 | 4.30 ± 0.59 | 4.12 ± 0.77 | 6.00 ± 1.00 | 4.05 ± 0.59 | 4.25 ± 0.70 | 6.63 ± 1.00 | |
|
| |||||||
| Chloroform fraction | 25 | 1.66 ± 0.52 | 2.77 ± 0.78 | 3.82 ± 0.66 | 1.68 ± 0.87 | 2.66 ± 0.66 | 4.55 ± 0.52 |
| 50 | 1.95 ± 0.65 | 4.88 ± 0.80 | 4.50 ± 0.60 | 2.04 ± 0.84 | 3.80 ± .87 | 5.44 ± 0.60 | |
| 100 | 3.66 ± 0.78 | 5.20 ± 0.59 | 7.60 ± 0.90 | 3.90 ± 0.60 | 4.97 ± 0.80 | 7.50 ± 1.10 | |
|
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| Ethyl acetate fraction | 25 | 1.88 ± 0.60 | 2.90 ± 0.63 | 3.98 ± 0.68 | 2.00 ± 0.88 | 3.01 ± 0.60 | 5.50 ± 0.63 |
| 50 | 2.20 ± 0.63 | 3.30 ± 0.60 | 4.50 ± 0.77 | 2.98 ± 0.76 | 4.15 ± 0.65 | 6.45 ± 0.60 | |
| 100 | 4.63 ± 0.70 | 5.20 ± 0.77 | 6.00 ± 0.88 | 4.40 ± 0.64 | 5.98 ± 0.65 | 7.80 ± 0.80 | |