Figure 2.

Unsupervised clustering analysis of the gene expression profiles of subfractionated peripheral blood cells. The dendrogram used for clustering using employed both correlations and average linkage for unsupervised analysis of the gene expression profile of peripheral blood. Significant up- or downregulated changes in gene expression (≥1.5-fold) in whole blood and CD4+ cells of CRC patients (compared to healthy volunteers) were observed for 3,243 and 2,459 genes at P-values <0.05, respectively, but few such changes were observed in CD8+ cells, CD14+ cells, or CD15+ cells (1,475, 128, and 333 genes; P <0.05, respectively).