Table 1.
Biological process networks for 1063 genes whose expression in peripheral CD4+ cells was positively correlated with serum eotaxin concentration.
| Networks | Total | P value | False discovery rate | In data | Network objects from active data |
|---|---|---|---|---|---|
| Immune response_Phagocytosis | 222 | 2.27E-08 | 1.81E-06 | 33 | ITGB2, Syk, IL-15, RhoA, Myosin I, C/EBP, Dectin-1, Fc gamma RII beta, ILT4, MSN (moesin), ERM proteins, SHPS-1, Fc epsilon RI gamma, MSR1, MANR, Lyn, PLC-gamma 2, IL-15RA, Btk, ILT2, Hck, TLR4, MARCO, MARCKS, MLCK, PLC-gamma, gp91-phox, p40-phox, PAK1, p67-phox, FGR, Fc alpha receptor, Fc gamma RII alpha |
|
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| Cell adhesion_Platelet aggregation | 158 | 2.34E-08 | 1.81E-06 | 27 | ITGB2, Syk, GAB2, PLA2, RhoA, Thrombospondin 1, G-protein beta/gamma, COX-1 (PTGS1), Fc epsilon RI gamma, c-Src, ENP1, THAS, cPLA2, PTAFR, Lyn, PLC-gamma 2, PKA-reg (cAMP-dependent), GP-IX, P2Y12, Gab, G-protein alpha-i family, G-protein alpha-i2, P2X1, MLCK, PLC-gamma, CD36, VAV-2 |
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| Cell adhesion_Amyloid proteins | 195 | 6.02E-06 | 3.09E-04 | 26 | RhoA, FZD1, Nicastrin, NOTCH2, APLP2 active fragment, G-protein beta/gamma, Jagged1, Nidogen, p120-catenin, Tcf(Lef), c-Src, Presenilin 2, FZD2, FZD5, Notch, Presenilin 1, Alpha-catenin, APLP2 precursor, Cathepsin D, MALS, Frizzled, ADAM9, PKC, PAK1, Plakoglobin, Presenilin |
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| Immune response_Antigen presentation | 197 | 6.23E-05 | 2.40E-03 | 24 | CIITA, ICAM1, MHC class II beta chain, CD1b, HLADPA1, CD1d, HLA-DQA1, JAK2, HA2Z, Fc epsilon RI gamma, IP-30, HLA-DM, HLA-DRB1, CD1a, Cathepsin S, LFA-3, MHC class II, HLA-DQB1, HLA-DRA1, HLA-DPB1, HLA-DRB4, CD86, CD74, RING6 |
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| Proliferation_Positive regulation cell proliferation | 221 | 1.48E-04 | 4.56E-03 | 25 | p21, HGF, RhoG, Beta-arrestin1, GAB2, Fra-1, RhoA, Galpha(i)-specific peptide GPCRs, JAK2, MTG16 (CBFA2T3), c-Src, VEGF-A, RasGRP4, PKA-reg (cAMP-dependent), G-protein alpha-15, TCIRG1 (Atp6i), CCR1, G-protein alpha-i family, M-CSF receptor, G-protein alpha-i2, CSDA, MLCK, c-Fes, FLT3, PAK1 |
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| Chemotaxis | 137 | 2.00E-04 | 5.14E-03 | 18 | ITGB2, Syk, C5aR, Fra-1, GRO-2, Prokineticin 2, PD-ECGF (TdRPase), IL-1 beta, Galpha(i)-specific peptide GPCRs, PLAUR (uPAR), MIG, Integrin, VEGF-A, PTAFR, CCR1, G-protein alpha-i family, Galpha(q)-specific peptide GPCRs, PLD1 |
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| Inflammation_IFN-gamma signaling | 109 | 4.08E-04 | 8.97E-03 | 15 | CIITA, p21, ITGB2, IL-15, IL-18, ICAM1, PKC-delta, K12, JAK2, MIG, c-Src, PLC-gamma 2, TLR4, PLC-gamma, Fc alpha receptor |
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| Apoptosis_Anti-apoptosis mediated by external signals via NF-kB | 111 | 4.97E-04 | 9.57E-03 | 15 | IL-15, MyD88, G-protein beta/gamma, TNF-R2, VEGF-A, CD30(TNFRSF8), CSF2RA, PKA-reg (cAMP-dependent), IL-15RA, G-protein alpha-i family, TLR4, Bcl-3, TL1A(TNFSF15), APRIL(TNFSF13), BAFF(TNFSF13B) |
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| Inflammation_Neutrophil activation | 215 | 6.08E-04 | 1.02E-02 | 23 | ITGB2, C5aR, PLA2, ICAM1, GRO-2, RhoA, PKC-delta, G-protein beta/gamma, TNF-R2, Galpha(i)-specific peptide GPCRs, Syntaxin 7, cPLA2, Btk, G-protein alpha-15, G-protein alpha-i family, G-protein alpha-i2, PA24A, gp91-phox, ALOX5, p40-phox, PAK1, p67-phox, PLD1 |
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| Inflammation_IL-4 signaling | 115 | 7.27E-04 | 1.02E-02 | 15 | HLADPA1, HLA-DQA1, JAK2, MHC class II, Bax, HLA-DQB1, HLA-DRA1, HLA-DPB1, HLA-DRB4, CD86, CD74, c-Fes, CD13, IL13RA1, Fc gamma RII alpha |