Table 2.
Biological process networks for 974 genes whose expression was negatively correlated with CD4+ peripheral blood cells and Eotaxin.
| Networks | Total | P value | False discovery rate | In data | Network objects from active data |
|---|---|---|---|---|---|
| Proteolysis_ECM remodeling | 85 | 5.38E-05 | 7.21E-03 | 10 | Collagen XIV, Tenascin-C, NEPH2, MMP-16, Protein C inhibitor, Serpin B12, COL18A1, Kallikrein 2, Trypsin II, Aggrecanase-1 |
|
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| Neurophysiological process_Transmission of nerve impulse | 212 | 3.13E-04 | 2.10E-02 | 15 | L-type Ca(II) channel, alpha 1C subunit, GABA-A receptor gamma-2 subunit, KCC2, mGluR3, Galpha(i)-specific peptide GPCRs, mGluR1, Galpha(q)-specific metabotropic glutamate GPCRs, Ionotropic glutamate receptor, Galpha(i)-specific metabotropic glutamate GPCRs, GluR6, Galpha(i)-specific amine GPCRs, CHT1, RIN, G-protein alpha-s, Kainate receptor |
|
| |||||
| Reproduction_Gonadotropin regulation | 199 | 1.64E-03 | 5.29E-02 | 13 | L-type Ca(II) channel, alpha 1C subunit, GABA-A receptor gamma-2 subunit, mGluR3, mGluR1, Galpha(q)-specific metabotropic glutamate GPCRs, Ionotropic glutamate receptor, Galpha(i)-specific metabotropic glutamate GPCRs, Secretogranin 1, Protein kinase G1, Adenylate cyclase, G-protein alpha-s, Protein kinase G, Kainate receptor |
|
| |||||
| Development_Blood vessel morphogenesis | 228 | 1.97E-03 | 5.29E-02 | 14 | PDE, Galpha(i)-specific peptide GPCRs, PDE7A, Endomucin, Galpha(q)-specific amine GPCRs, Galpha(i)-specific amine GPCRs, Protein kinase G1, Galpha(q)-specific peptide GPCRs, COL18A1, Tissue kallikreins, Neuropilin-1, G-protein alpha-s, Protein kinase G, Transferrin |
|
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| Reproduction_Spermatogenesis, motility and copulation | 228 | 1.97E-03 | 5.29E-02 | 14 | PDGF receptor, MFGE8, IGF-1 receptor, Ropporin, MSK1, S5AR2, BBS2, Tissue kallikreins, BMP2, Kallikrein 2, SOX5, CREM (activators), ZFP37, PDGF-R-alpha |
|
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| Proteolysis_Connective tissue degradation | 119 | 3.23E-03 | 6.80E-02 | 9 | Trypsin, Tenascin-C, MMP-16, Protein C inhibitor, Serpin B12, Tissue kallikreins, Kallikrein 2, Trypsin II, Aggrecanase-1 |
|
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| Development_Neurogenesis in general | 192 | 3.55E-03 | 6.80E-02 | 12 | WNT4, RET, CHRM, Neuromodulin, WNT7A, WNT, Galpha(q)-specific amine GPCRs, Galpha(i)-specific amine GPCRs, HDAC7, ACM3, SOX8, SOX14 |
|
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| Development_Cartilage development | 66 | 6.45E-03 | 1.08E-01 | 6 | TR-alpha, Noggin, COL1A2, BMP2, SOX5, Aggrecanase-1 |
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| Reproduction_Male sex differentiation | 243 | 8.98E-03 | 1.30E-01 | 13 | AP-2A, PDGF receptor, Olfactory receptor, RET, IGF-1 receptor, MSK1, S5AR2, HSF2, BMP2, SOX5, CREM (activators), ZFP37, PDGF-R-alpha |
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| Reproduction_GnRH signaling pathway | 166 | 9.70E-03 | 1.30E-01 | 10 | GABA-A receptor gamma-2 subunit, mGluR3, mGluR1, Galpha(q)-specific metabotropic glutamate GPCRs, Ionotropic glutamate receptor, Galpha(i)-specific metabotropic glutamate GPCRs, Protein kinase G1, G-protein alpha-s, Protein kinase G, Kainate receptor |